منابع مشابه
Assessing Blinding in Clinical Trials
The interaction between the patient’s expected outcome of an intervention and the inherent effects of that intervention can have extraordinary effects. Thus in clinical trials an effort is made to conceal the nature of the administered intervention from the participants in the trial i.e. to blind it. Yet, in practice perfect blinding is impossible to ensure or even verify. The current standard ...
متن کاملEffective patient blinding during hyperbaric trials.
Hyperbaric medicine is applied for several disease states. Laboratory evidence is compelling but clinical efficacy remains incompletely validated. The standard by which supportive research is measured is termed evidence-based medicine, with results of randomized, blinded trials being most desirable. Blinding patients during hyperbaric exposure poses unique challenges. Few such studies are repor...
متن کاملAssessment of blinding in clinical trials.
Success of blinding is a fundamental issue in many clinical trials. The validity of a trial may be questioned if this important assumption is violated. Although thousands of ostensibly double-blind trials are conducted annually and investigators acknowledge the importance of blinding, attempts to measure the effectiveness of blinding are rarely discussed. Several published papers proposed ways ...
متن کاملRandomisation and blinding in clinical trials
High quality clinical trials are designed to reduce bias, to increase the confidence that the reader can place in the conclusions of the trial. This article evaluates the role of randomisation and blinding to prevent bias and how to best implement them in a trial.
متن کاملReporting Methods of Blinding in Randomized Trials Assessing Nonpharmacological Treatments
BACKGROUND Blinding is a cornerstone of treatment evaluation. Blinding is more difficult to obtain in trials assessing nonpharmacological treatment and frequently relies on "creative" (nonstandard) methods. The purpose of this study was to systematically describe the strategies used to obtain blinding in a sample of randomized controlled trials of nonpharmacological treatment. METHODS AND FIN...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1991
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.158.4.573c